Nasdaq · Common stock
Spruce Biosciences (SPRB)
$43.99 −$1.16 (−2.57%)
- Day’s range
- $43.62–$45.47
- Volume
- 66,482
SPRB price history
SPRB closed at $43.99 on Oct. 26, 2026. Over the past year, its daily close ranged from $38.98 on Oct. 14, 2026 to $127.00 on Nov. 7, 2025.
Data table: SPRB daily closes, the past year
| Date | Close |
|---|---|
| Oct. 26, 2026 | $43.99 |
| Oct. 23, 2026 | $45.15 |
| Oct. 22, 2026 | $46.00 |
| Oct. 21, 2026 | $42.73 |
| Oct. 20, 2026 | $41.23 |
| Oct. 19, 2026 | $40.40 |
| Oct. 16, 2026 | $39.65 |
| Oct. 15, 2026 | $41.47 |
| Oct. 14, 2026 | $38.98 |
| Oct. 13, 2026 | $40.35 |
| Oct. 12, 2026 | $42.87 |
| Oct. 9, 2026 | $44.05 |
| Oct. 8, 2026 | $45.54 |
| Oct. 7, 2026 | $44.40 |
| Oct. 6, 2026 | $42.79 |
| Oct. 5, 2026 | $45.42 |
| Oct. 2, 2026 | $45.71 |
| Oct. 1, 2026 | $44.77 |
| Sept. 30, 2026 | $48.58 |
| Sept. 29, 2026 | $47.27 |
| Sept. 28, 2026 | $47.51 |
| Sept. 25, 2026 | $48.72 |
| Sept. 24, 2026 | $49.02 |
| Sept. 23, 2026 | $49.42 |
| Sept. 22, 2026 | $49.99 |
| Sept. 21, 2026 | $53.70 |
| Sept. 18, 2026 | $53.05 |
| Sept. 17, 2026 | $53.86 |
| Sept. 16, 2026 | $54.16 |
| Sept. 15, 2026 | $55.17 |
| Sept. 14, 2026 | $56.85 |
| Sept. 11, 2026 | $53.70 |
| Sept. 10, 2026 | $54.35 |
| Sept. 9, 2026 | $55.74 |
| Sept. 8, 2026 | $59.09 |
| Sept. 4, 2026 | $57.93 |
| Sept. 3, 2026 | $57.71 |
| Sept. 2, 2026 | $59.67 |
| Sept. 1, 2026 | $55.60 |
| Aug. 31, 2026 | $58.97 |
| Aug. 28, 2026 | $60.78 |
| Aug. 27, 2026 | $63.30 |
| Aug. 26, 2026 | $61.48 |
| Aug. 25, 2026 | $63.40 |
| Aug. 24, 2026 | $58.65 |
| Aug. 21, 2026 | $51.58 |
| Aug. 20, 2026 | $51.99 |
| Aug. 19, 2026 | $52.96 |
| Aug. 18, 2026 | $52.85 |
| Aug. 17, 2026 | $52.92 |
| Aug. 14, 2026 | $52.64 |
| Aug. 13, 2026 | $49.77 |
| Aug. 12, 2026 | $47.07 |
| Aug. 11, 2026 | $46.41 |
| Aug. 10, 2026 | $46.20 |
| Aug. 7, 2026 | $46.87 |
| Aug. 6, 2026 | $46.42 |
| Aug. 5, 2026 | $46.61 |
| Aug. 4, 2026 | $46.26 |
| Aug. 3, 2026 | $43.14 |
| July 31, 2026 | $42.83 |
| July 30, 2026 | $43.37 |
| July 29, 2026 | $41.45 |
| July 28, 2026 | $41.60 |
| July 27, 2026 | $41.99 |
| July 24, 2026 | $43.08 |
| July 23, 2026 | $44.99 |
| July 22, 2026 | $44.60 |
| July 21, 2026 | $45.68 |
| July 20, 2026 | $44.50 |
| July 17, 2026 | $43.54 |
| July 16, 2026 | $44.28 |
| July 15, 2026 | $45.44 |
| July 14, 2026 | $46.36 |
| July 13, 2026 | $48.38 |
| July 10, 2026 | $50.07 |
| July 9, 2026 | $51.74 |
| July 8, 2026 | $49.80 |
| July 7, 2026 | $50.77 |
| July 6, 2026 | $51.85 |
| July 2, 2026 | $52.51 |
| July 1, 2026 | $52.55 |
| June 30, 2026 | $54.00 |
| June 29, 2026 | $55.88 |
| June 26, 2026 | $55.11 |
| June 25, 2026 | $52.77 |
| June 24, 2026 | $51.87 |
| June 23, 2026 | $52.14 |
| June 22, 2026 | $54.70 |
| June 18, 2026 | $52.36 |
| June 17, 2026 | $48.76 |
| June 16, 2026 | $47.10 |
| June 15, 2026 | $49.91 |
| June 12, 2026 | $51.89 |
| June 11, 2026 | $49.11 |
| June 10, 2026 | $47.13 |
| June 9, 2026 | $49.03 |
| June 8, 2026 | $49.32 |
| June 5, 2026 | $50.43 |
| June 4, 2026 | $53.17 |
| June 3, 2026 | $49.05 |
| June 2, 2026 | $49.30 |
| June 1, 2026 | $50.70 |
| May 29, 2026 | $51.27 |
| May 28, 2026 | $49.19 |
| May 27, 2026 | $49.52 |
| May 26, 2026 | $51.81 |
| May 22, 2026 | $51.08 |
| May 21, 2026 | $52.70 |
| May 20, 2026 | $51.52 |
| May 19, 2026 | $48.25 |
| May 18, 2026 | $51.41 |
| May 15, 2026 | $53.78 |
| May 14, 2026 | $59.00 |
| May 13, 2026 | $57.55 |
| May 12, 2026 | $56.67 |
| May 11, 2026 | $56.40 |
| May 8, 2026 | $56.50 |
| May 7, 2026 | $56.57 |
| May 6, 2026 | $57.87 |
| May 5, 2026 | $59.34 |
| May 4, 2026 | $59.37 |
| May 1, 2026 | $57.28 |
| April 30, 2026 | $57.32 |
| April 29, 2026 | $55.52 |
| April 28, 2026 | $54.77 |
| April 27, 2026 | $57.18 |
| April 24, 2026 | $54.37 |
| April 23, 2026 | $54.01 |
| April 22, 2026 | $52.36 |
| April 21, 2026 | $51.69 |
| April 20, 2026 | $69.90 |
| April 17, 2026 | $70.30 |
| April 16, 2026 | $67.90 |
| April 15, 2026 | $69.32 |
| April 14, 2026 | $67.80 |
| April 13, 2026 | $64.51 |
| April 10, 2026 | $63.63 |
| April 9, 2026 | $66.01 |
| April 8, 2026 | $63.65 |
| April 7, 2026 | $62.15 |
| April 6, 2026 | $63.01 |
| April 2, 2026 | $70.50 |
| April 1, 2026 | $69.53 |
| March 31, 2026 | $65.35 |
| March 30, 2026 | $58.53 |
| March 27, 2026 | $63.04 |
| March 26, 2026 | $69.11 |
| March 25, 2026 | $69.97 |
| March 24, 2026 | $64.36 |
| March 23, 2026 | $58.83 |
| March 20, 2026 | $58.40 |
| March 19, 2026 | $59.05 |
| March 18, 2026 | $58.75 |
| March 17, 2026 | $64.30 |
| March 16, 2026 | $60.95 |
| March 13, 2026 | $60.06 |
| March 12, 2026 | $59.90 |
| March 11, 2026 | $64.18 |
| March 10, 2026 | $62.79 |
| March 9, 2026 | $62.11 |
| March 6, 2026 | $55.87 |
| March 5, 2026 | $53.78 |
| March 4, 2026 | $57.54 |
| March 3, 2026 | $55.83 |
| March 2, 2026 | $54.21 |
| Feb. 27, 2026 | $54.94 |
| Feb. 26, 2026 | $58.55 |
| Feb. 25, 2026 | $58.73 |
| Feb. 24, 2026 | $58.22 |
| Feb. 23, 2026 | $53.58 |
| Feb. 20, 2026 | $49.72 |
| Feb. 19, 2026 | $52.62 |
| Feb. 18, 2026 | $53.48 |
| Feb. 17, 2026 | $58.25 |
| Feb. 13, 2026 | $66.29 |
| Feb. 12, 2026 | $82.96 |
| Feb. 11, 2026 | $82.69 |
| Feb. 10, 2026 | $83.63 |
| Feb. 9, 2026 | $79.07 |
| Feb. 6, 2026 | $72.40 |
| Feb. 5, 2026 | $70.85 |
| Feb. 4, 2026 | $79.23 |
| Feb. 3, 2026 | $83.49 |
| Feb. 2, 2026 | $77.99 |
| Jan. 30, 2026 | $77.55 |
| Jan. 29, 2026 | $79.86 |
| Jan. 28, 2026 | $81.90 |
| Jan. 27, 2026 | $84.24 |
| Jan. 26, 2026 | $82.69 |
| Jan. 23, 2026 | $81.52 |
| Jan. 22, 2026 | $85.24 |
| Jan. 21, 2026 | $78.92 |
| Jan. 20, 2026 | $71.46 |
| Jan. 16, 2026 | $73.53 |
| Jan. 15, 2026 | $74.89 |
| Jan. 14, 2026 | $78.37 |
| Jan. 13, 2026 | $81.50 |
| Jan. 12, 2026 | $77.80 |
| Jan. 9, 2026 | $79.99 |
| Jan. 8, 2026 | $73.70 |
| Jan. 7, 2026 | $78.09 |
| Jan. 6, 2026 | $80.57 |
| Jan. 5, 2026 | $82.12 |
| Jan. 2, 2026 | $90.70 |
| Dec. 31, 2025 | $87.11 |
| Dec. 30, 2025 | $82.67 |
| Dec. 29, 2025 | $82.30 |
| Dec. 26, 2025 | $85.74 |
| Dec. 24, 2025 | $84.00 |
| Dec. 23, 2025 | $83.74 |
| Dec. 22, 2025 | $82.82 |
| Dec. 19, 2025 | $78.74 |
| Dec. 18, 2025 | $76.77 |
| Dec. 17, 2025 | $75.84 |
| Dec. 16, 2025 | $78.00 |
| Dec. 15, 2025 | $80.67 |
| Dec. 12, 2025 | $83.40 |
| Dec. 11, 2025 | $88.41 |
| Dec. 10, 2025 | $85.67 |
| Dec. 9, 2025 | $95.15 |
| Dec. 8, 2025 | $81.68 |
| Dec. 5, 2025 | $79.99 |
| Dec. 4, 2025 | $90.44 |
| Dec. 3, 2025 | $90.16 |
| Dec. 2, 2025 | $89.20 |
| Dec. 1, 2025 | $83.11 |
| Nov. 28, 2025 | $100.00 |
| Nov. 26, 2025 | $110.00 |
| Nov. 25, 2025 | $104.57 |
| Nov. 24, 2025 | $107.00 |
| Nov. 21, 2025 | $105.00 |
| Nov. 20, 2025 | $102.61 |
| Nov. 19, 2025 | $111.00 |
| Nov. 18, 2025 | $115.00 |
| Nov. 17, 2025 | $108.84 |
| Nov. 14, 2025 | $106.35 |
| Nov. 13, 2025 | $112.57 |
| Nov. 12, 2025 | $102.20 |
| Nov. 11, 2025 | $112.66 |
| Nov. 10, 2025 | $115.61 |
| Nov. 7, 2025 | $127.00 |
| Nov. 6, 2025 | $119.29 |
| Nov. 5, 2025 | $120.00 |
| Nov. 4, 2025 | $104.94 |
| Nov. 3, 2025 | $104.75 |
| Oct. 31, 2025 | $110.10 |
| Oct. 30, 2025 | $107.25 |
| Oct. 29, 2025 | $118.00 |
| Oct. 28, 2025 | $124.51 |
| Oct. 27, 2025 | $123.02 |
Key figures
- 52-week range
- $38.98–$133.24Low Oct. 14, 2026; high Oct. 24, 2025
- Average daily volume
- 80,391Past 3 months
- Market value
- $126.4M
- Dividend yield
- —
- From 52-week high
- −66.98%
Price change
- 1 month
- −9.71%
- 3 months
- +2.11%
- Year to date
- −49.50%
- 1 year
- −66.98%
$1,000 a year ago
$1,000 put into SPRB at the close on Oct. 24, 2025 would be worth $330.
Price only, dividends not included.
What Wall Street says about SPRB
In the past 90 days, Wall Street firms published 4 rating or price-target actions on SPRB: 1 new rating, 1 reiterated rating and 2 lowered price targets.
| Action | Rating | |||
|---|---|---|---|---|
| Citizens | Reiterates | Market outperform | $144 | |
| Lake Street | Initiates coverage | Buy | $149 | |
| Guggenheim | Cuts target | Buy | $123 to $104 | |
| Citizens | Cuts target | Market outperform | $150 to $144 |
Ratings and price targets are the firms’ own opinions, reported as published.
Not investment advice.
About Spruce Biosciences, Inc. Common Stock
Spruce Biosciences Inc is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for rare endocrine disorders with unmet medical needs. The company develops biologics and small-molecule product candidates aimed at addressing diseases with unmet medical needs and limited or no approved therapies. Its product candidate, TA-ERT for the treatment of Mucopolysaccharidosis Type IIIB (MPS IIIB), is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) intended as an enzyme replacement therapy for patients who lack rhNAGLU enzyme activity. TA-ERT is designed to restore rhNAGLU enzyme activity in the central nervous system following intracerebroventricular injection and promote clearance of heparan sulfate in the brain.
- Headquarters
- South San Francisco, Calif.
- Employees
- 8
- Listed
- Oct. 9, 2020
- Sector
- Health care
- Industry
- Pharmaceutical preparations
In WallStreetDigest editions
No WallStreetDigest article about SPRB is on the site yet.