Nasdaq · Common stock
Spyre Therapeutics (SYRE)
$92.91 +$2.58 (+2.86%)
- Day’s range
- $90.35–$94.19
- Volume
- 637,158
SYRE price history
SYRE closed at $92.91 on Oct. 26, 2026. Over the past year, its daily close ranged from $22.18 on Nov. 10, 2025 to $108.92 on Aug. 19, 2026.
Data table: SYRE daily closes, the past year
| Date | Close |
|---|---|
| Oct. 26, 2026 | $92.91 |
| Oct. 23, 2026 | $90.33 |
| Oct. 22, 2026 | $92.33 |
| Oct. 21, 2026 | $92.95 |
| Oct. 20, 2026 | $91.40 |
| Oct. 19, 2026 | $84.72 |
| Oct. 16, 2026 | $79.90 |
| Oct. 15, 2026 | $80.10 |
| Oct. 14, 2026 | $78.63 |
| Oct. 13, 2026 | $80.45 |
| Oct. 12, 2026 | $85.90 |
| Oct. 9, 2026 | $85.69 |
| Oct. 8, 2026 | $79.90 |
| Oct. 7, 2026 | $80.85 |
| Oct. 6, 2026 | $80.11 |
| Oct. 5, 2026 | $92.72 |
| Oct. 2, 2026 | $93.19 |
| Oct. 1, 2026 | $89.93 |
| Sept. 30, 2026 | $89.03 |
| Sept. 29, 2026 | $84.72 |
| Sept. 28, 2026 | $85.79 |
| Sept. 25, 2026 | $85.69 |
| Sept. 24, 2026 | $87.09 |
| Sept. 23, 2026 | $88.17 |
| Sept. 22, 2026 | $91.97 |
| Sept. 21, 2026 | $92.03 |
| Sept. 18, 2026 | $90.25 |
| Sept. 17, 2026 | $92.68 |
| Sept. 16, 2026 | $91.17 |
| Sept. 15, 2026 | $90.95 |
| Sept. 14, 2026 | $90.80 |
| Sept. 11, 2026 | $90.60 |
| Sept. 10, 2026 | $88.71 |
| Sept. 9, 2026 | $86.93 |
| Sept. 8, 2026 | $90.79 |
| Sept. 4, 2026 | $88.98 |
| Sept. 3, 2026 | $87.25 |
| Sept. 2, 2026 | $87.05 |
| Sept. 1, 2026 | $88.50 |
| Aug. 31, 2026 | $89.33 |
| Aug. 28, 2026 | $90.36 |
| Aug. 27, 2026 | $93.62 |
| Aug. 26, 2026 | $93.61 |
| Aug. 25, 2026 | $107.36 |
| Aug. 24, 2026 | $106.65 |
| Aug. 21, 2026 | $106.49 |
| Aug. 20, 2026 | $107.79 |
| Aug. 19, 2026 | $108.92 |
| Aug. 18, 2026 | $107.82 |
| Aug. 17, 2026 | $104.60 |
| Aug. 14, 2026 | $103.63 |
| Aug. 13, 2026 | $101.85 |
| Aug. 12, 2026 | $104.09 |
| Aug. 11, 2026 | $102.74 |
| Aug. 10, 2026 | $105.33 |
| Aug. 7, 2026 | $104.91 |
| Aug. 6, 2026 | $103.42 |
| Aug. 5, 2026 | $104.35 |
| Aug. 4, 2026 | $104.94 |
| Aug. 3, 2026 | $94.93 |
| July 31, 2026 | $98.33 |
| July 30, 2026 | $101.50 |
| July 29, 2026 | $97.87 |
| July 28, 2026 | $99.96 |
| July 27, 2026 | $100.04 |
| July 24, 2026 | $102.13 |
| July 23, 2026 | $99.99 |
| July 22, 2026 | $99.17 |
| July 21, 2026 | $102.70 |
| July 20, 2026 | $97.33 |
| July 17, 2026 | $100.23 |
| July 16, 2026 | $94.12 |
| July 15, 2026 | $102.07 |
| July 14, 2026 | $98.95 |
| July 13, 2026 | $93.73 |
| July 10, 2026 | $97.74 |
| July 9, 2026 | $98.75 |
| July 8, 2026 | $95.40 |
| July 7, 2026 | $94.23 |
| July 6, 2026 | $88.74 |
| July 2, 2026 | $86.63 |
| July 1, 2026 | $88.89 |
| June 30, 2026 | $88.78 |
| June 29, 2026 | $90.16 |
| June 26, 2026 | $87.89 |
| June 25, 2026 | $88.67 |
| June 24, 2026 | $86.24 |
| June 23, 2026 | $97.05 |
| June 22, 2026 | $100.32 |
| June 18, 2026 | $88.34 |
| June 17, 2026 | $87.49 |
| June 16, 2026 | $83.41 |
| June 15, 2026 | $83.58 |
| June 12, 2026 | $80.79 |
| June 11, 2026 | $80.77 |
| June 10, 2026 | $75.08 |
| June 9, 2026 | $76.44 |
| June 8, 2026 | $72.00 |
| June 5, 2026 | $73.65 |
| June 4, 2026 | $78.48 |
| June 3, 2026 | $73.52 |
| June 2, 2026 | $69.16 |
| June 1, 2026 | $70.54 |
| May 29, 2026 | $73.50 |
| May 28, 2026 | $72.11 |
| May 27, 2026 | $72.51 |
| May 26, 2026 | $73.65 |
| May 22, 2026 | $74.05 |
| May 21, 2026 | $74.32 |
| May 20, 2026 | $71.92 |
| May 19, 2026 | $66.62 |
| May 18, 2026 | $70.08 |
| May 15, 2026 | $74.92 |
| May 14, 2026 | $75.65 |
| May 13, 2026 | $76.31 |
| May 12, 2026 | $75.04 |
| May 11, 2026 | $76.43 |
| May 8, 2026 | $75.05 |
| May 7, 2026 | $73.10 |
| May 6, 2026 | $73.00 |
| May 5, 2026 | $71.01 |
| May 4, 2026 | $69.13 |
| May 1, 2026 | $69.42 |
| April 30, 2026 | $74.45 |
| April 29, 2026 | $71.89 |
| April 28, 2026 | $68.63 |
| April 27, 2026 | $71.90 |
| April 24, 2026 | $69.67 |
| April 23, 2026 | $69.24 |
| April 22, 2026 | $73.00 |
| April 21, 2026 | $71.27 |
| April 20, 2026 | $73.39 |
| April 17, 2026 | $73.01 |
| April 16, 2026 | $69.70 |
| April 15, 2026 | $68.99 |
| April 14, 2026 | $64.01 |
| April 13, 2026 | $63.27 |
| April 10, 2026 | $51.29 |
| April 9, 2026 | $51.77 |
| April 8, 2026 | $51.98 |
| April 7, 2026 | $51.20 |
| April 6, 2026 | $48.98 |
| April 2, 2026 | $47.58 |
| April 1, 2026 | $48.90 |
| March 31, 2026 | $50.44 |
| March 30, 2026 | $45.42 |
| March 27, 2026 | $47.31 |
| March 26, 2026 | $47.52 |
| March 25, 2026 | $45.68 |
| March 24, 2026 | $42.22 |
| March 23, 2026 | $42.76 |
| March 20, 2026 | $41.25 |
| March 19, 2026 | $42.31 |
| March 18, 2026 | $43.06 |
| March 17, 2026 | $43.95 |
| March 16, 2026 | $44.07 |
| March 13, 2026 | $39.89 |
| March 12, 2026 | $40.41 |
| March 11, 2026 | $41.50 |
| March 10, 2026 | $41.57 |
| March 9, 2026 | $41.07 |
| March 6, 2026 | $40.15 |
| March 5, 2026 | $40.59 |
| March 4, 2026 | $41.00 |
| March 3, 2026 | $40.07 |
| March 2, 2026 | $42.49 |
| Feb. 27, 2026 | $43.01 |
| Feb. 26, 2026 | $43.15 |
| Feb. 25, 2026 | $43.88 |
| Feb. 24, 2026 | $43.45 |
| Feb. 23, 2026 | $44.18 |
| Feb. 20, 2026 | $43.21 |
| Feb. 19, 2026 | $37.81 |
| Feb. 18, 2026 | $36.60 |
| Feb. 17, 2026 | $35.95 |
| Feb. 13, 2026 | $36.63 |
| Feb. 12, 2026 | $34.84 |
| Feb. 11, 2026 | $33.92 |
| Feb. 10, 2026 | $33.56 |
| Feb. 9, 2026 | $33.96 |
| Feb. 6, 2026 | $35.12 |
| Feb. 5, 2026 | $32.94 |
| Feb. 4, 2026 | $32.07 |
| Feb. 3, 2026 | $33.29 |
| Feb. 2, 2026 | $32.75 |
| Jan. 30, 2026 | $31.98 |
| Jan. 29, 2026 | $33.58 |
| Jan. 28, 2026 | $33.14 |
| Jan. 27, 2026 | $33.36 |
| Jan. 26, 2026 | $32.29 |
| Jan. 23, 2026 | $32.03 |
| Jan. 22, 2026 | $34.09 |
| Jan. 21, 2026 | $33.99 |
| Jan. 20, 2026 | $33.73 |
| Jan. 16, 2026 | $33.24 |
| Jan. 15, 2026 | $33.09 |
| Jan. 14, 2026 | $33.16 |
| Jan. 13, 2026 | $31.53 |
| Jan. 12, 2026 | $32.80 |
| Jan. 9, 2026 | $30.61 |
| Jan. 8, 2026 | $30.14 |
| Jan. 7, 2026 | $31.05 |
| Jan. 6, 2026 | $30.33 |
| Jan. 5, 2026 | $29.96 |
| Jan. 2, 2026 | $30.58 |
| Dec. 31, 2025 | $32.76 |
| Dec. 30, 2025 | $31.88 |
| Dec. 29, 2025 | $32.56 |
| Dec. 26, 2025 | $32.94 |
| Dec. 24, 2025 | $33.05 |
| Dec. 23, 2025 | $33.23 |
| Dec. 22, 2025 | $34.20 |
| Dec. 19, 2025 | $33.40 |
| Dec. 18, 2025 | $33.47 |
| Dec. 17, 2025 | $33.06 |
| Dec. 16, 2025 | $32.97 |
| Dec. 15, 2025 | $33.34 |
| Dec. 12, 2025 | $33.62 |
| Dec. 11, 2025 | $34.36 |
| Dec. 10, 2025 | $34.66 |
| Dec. 9, 2025 | $33.68 |
| Dec. 8, 2025 | $34.63 |
| Dec. 5, 2025 | $33.45 |
| Dec. 4, 2025 | $33.51 |
| Dec. 3, 2025 | $32.20 |
| Dec. 2, 2025 | $28.40 |
| Dec. 1, 2025 | $28.66 |
| Nov. 28, 2025 | $30.00 |
| Nov. 26, 2025 | $29.75 |
| Nov. 25, 2025 | $29.20 |
| Nov. 24, 2025 | $26.97 |
| Nov. 21, 2025 | $24.26 |
| Nov. 20, 2025 | $23.47 |
| Nov. 19, 2025 | $24.30 |
| Nov. 18, 2025 | $24.10 |
| Nov. 17, 2025 | $24.36 |
| Nov. 14, 2025 | $23.50 |
| Nov. 13, 2025 | $22.63 |
| Nov. 12, 2025 | $23.43 |
| Nov. 11, 2025 | $23.35 |
| Nov. 10, 2025 | $22.18 |
| Nov. 7, 2025 | $22.52 |
| Nov. 6, 2025 | $22.39 |
| Nov. 5, 2025 | $22.85 |
| Nov. 4, 2025 | $22.98 |
| Nov. 3, 2025 | $23.78 |
| Oct. 31, 2025 | $24.46 |
| Oct. 30, 2025 | $24.26 |
| Oct. 29, 2025 | $23.83 |
| Oct. 28, 2025 | $24.64 |
| Oct. 27, 2025 | $24.57 |
Key figures
- 52-week range
- $22.18–$108.92Low Nov. 10, 2025; high Aug. 19, 2026
- Average daily volume
- 1.2MPast 3 months
- Market value
- $9.47B
- Dividend yield
- —
- From 52-week high
- −14.70%
Price change
- 1 month
- +8.43%
- 3 months
- −9.03%
- Year to date
- +183.61%
- 1 year
- +297.56%
$1,000 a year ago
$1,000 put into SYRE at the close on Oct. 24, 2025 would be worth $3,976.
Price only, dividends not included.
What Wall Street says about SYRE
In the past 90 days, Wall Street firms published 13 rating or price-target actions on SYRE: 2 new ratings, 4 reiterated ratings, 4 raised price targets and 3 lowered price targets.
| Action | Rating | |||
|---|---|---|---|---|
| BTIG | Reiterates | Buy | $121 | |
| UBS | Initiates coverage | Buy | $120 | |
| BTIG | Reiterates | Buy | $121 | |
| JP Morgan | Initiates coverage | Overweight | $110 | |
| Wedbush | Reiterates | Outperform | $123 | |
| BTIG | Reiterates | Buy | $121 | |
| BTIG | Cuts target | Buy | $132 to $121 | |
| Deutsche Bank | Cuts target | Buy | $135 to $127 | |
| Wedbush | Cuts target | Outperform | $130 to $123 | |
| BTIG | Raises target | Buy | $112 to $132 | |
| Guggenheim | Raises target | Buy | $115 to $130 | |
| Wedbush | Raises target | Outperform | $100 to $130 | |
| Wells Fargo | Raises target | Overweight | $90 to $115 |
Ratings and price targets are the firms’ own opinions, reported as published.
Not investment advice.
About Spyre Therapeutics, Inc. Common Stock
Spyre Therapeutics Inc is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (IBD) and rheumatic diseases. Spyre's pipeline includes extended half-life antibodies targeting α4β7, TL1A, and IL-23 in development as monotherapies and pair-wise combinations. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.
- Headquarters
- Waltham, Mass.
- Employees
- 112
- Listed
- April 7, 2016
- Sector
- Health care
- Industry
- Pharmaceutical preparations
In WallStreetDigest editions
No WallStreetDigest article about SYRE is on the site yet.