Nasdaq · Common stock
Upstream Bio (UPB)
$2.75 +$0.01 (+0.36%)
- Day’s range
- $2.72–$2.97
- Volume
- 983,843
UPB price history
UPB closed at $2.75 on Oct. 26, 2026. Over the past year, its daily close ranged from $2.74 on Oct. 23, 2026 to $32.60 on Jan. 13, 2026.
Data table: UPB daily closes, the past year
| Date | Close |
|---|---|
| Oct. 26, 2026 | $2.75 |
| Oct. 23, 2026 | $2.74 |
| Oct. 22, 2026 | $2.99 |
| Oct. 21, 2026 | $2.80 |
| Oct. 20, 2026 | $2.82 |
| Oct. 19, 2026 | $2.80 |
| Oct. 16, 2026 | $2.76 |
| Oct. 15, 2026 | $3.37 |
| Oct. 14, 2026 | $3.42 |
| Oct. 13, 2026 | $3.55 |
| Oct. 12, 2026 | $4.17 |
| Oct. 9, 2026 | $4.70 |
| Oct. 8, 2026 | $4.55 |
| Oct. 7, 2026 | $4.61 |
| Oct. 6, 2026 | $4.59 |
| Oct. 5, 2026 | $4.85 |
| Oct. 2, 2026 | $5.04 |
| Oct. 1, 2026 | $5.04 |
| Sept. 30, 2026 | $5.27 |
| Sept. 29, 2026 | $5.19 |
| Sept. 28, 2026 | $5.30 |
| Sept. 25, 2026 | $5.36 |
| Sept. 24, 2026 | $5.17 |
| Sept. 23, 2026 | $5.19 |
| Sept. 22, 2026 | $5.49 |
| Sept. 21, 2026 | $5.37 |
| Sept. 18, 2026 | $5.34 |
| Sept. 17, 2026 | $5.31 |
| Sept. 16, 2026 | $5.33 |
| Sept. 15, 2026 | $5.48 |
| Sept. 14, 2026 | $5.81 |
| Sept. 11, 2026 | $5.73 |
| Sept. 10, 2026 | $5.75 |
| Sept. 9, 2026 | $5.96 |
| Sept. 8, 2026 | $6.19 |
| Sept. 4, 2026 | $6.01 |
| Sept. 3, 2026 | $6.08 |
| Sept. 2, 2026 | $6.48 |
| Sept. 1, 2026 | $6.55 |
| Aug. 31, 2026 | $6.62 |
| Aug. 28, 2026 | $6.69 |
| Aug. 27, 2026 | $6.79 |
| Aug. 26, 2026 | $7.13 |
| Aug. 25, 2026 | $7.18 |
| Aug. 24, 2026 | $6.61 |
| Aug. 21, 2026 | $6.97 |
| Aug. 20, 2026 | $6.85 |
| Aug. 19, 2026 | $7.52 |
| Aug. 18, 2026 | $6.85 |
| Aug. 17, 2026 | $7.14 |
| Aug. 14, 2026 | $7.07 |
| Aug. 13, 2026 | $6.91 |
| Aug. 12, 2026 | $6.91 |
| Aug. 11, 2026 | $7.09 |
| Aug. 10, 2026 | $7.44 |
| Aug. 7, 2026 | $7.25 |
| Aug. 6, 2026 | $6.87 |
| Aug. 5, 2026 | $6.74 |
| Aug. 4, 2026 | $6.79 |
| Aug. 3, 2026 | $6.42 |
| July 31, 2026 | $6.31 |
| July 30, 2026 | $6.57 |
| July 29, 2026 | $6.41 |
| July 28, 2026 | $6.40 |
| July 27, 2026 | $6.40 |
| July 24, 2026 | $6.41 |
| July 23, 2026 | $6.40 |
| July 22, 2026 | $6.59 |
| July 21, 2026 | $6.98 |
| July 20, 2026 | $6.98 |
| July 17, 2026 | $7.01 |
| July 16, 2026 | $7.23 |
| July 15, 2026 | $7.27 |
| July 14, 2026 | $7.14 |
| July 13, 2026 | $7.28 |
| July 10, 2026 | $7.53 |
| July 9, 2026 | $7.81 |
| July 8, 2026 | $7.98 |
| July 7, 2026 | $7.86 |
| July 6, 2026 | $7.40 |
| July 2, 2026 | $7.51 |
| July 1, 2026 | $7.28 |
| June 30, 2026 | $6.92 |
| June 29, 2026 | $6.93 |
| June 26, 2026 | $6.75 |
| June 25, 2026 | $6.36 |
| June 24, 2026 | $6.35 |
| June 23, 2026 | $6.32 |
| June 22, 2026 | $6.30 |
| June 18, 2026 | $6.25 |
| June 17, 2026 | $6.15 |
| June 16, 2026 | $5.92 |
| June 15, 2026 | $6.10 |
| June 12, 2026 | $6.10 |
| June 11, 2026 | $6.38 |
| June 10, 2026 | $6.28 |
| June 9, 2026 | $6.69 |
| June 8, 2026 | $6.45 |
| June 5, 2026 | $7.05 |
| June 4, 2026 | $7.43 |
| June 3, 2026 | $7.63 |
| June 2, 2026 | $7.25 |
| June 1, 2026 | $8.08 |
| May 29, 2026 | $8.36 |
| May 28, 2026 | $8.32 |
| May 27, 2026 | $8.26 |
| May 26, 2026 | $8.21 |
| May 22, 2026 | $8.37 |
| May 21, 2026 | $8.46 |
| May 20, 2026 | $8.41 |
| May 19, 2026 | $8.03 |
| May 18, 2026 | $8.51 |
| May 15, 2026 | $9.09 |
| May 14, 2026 | $8.79 |
| May 13, 2026 | $9.36 |
| May 12, 2026 | $8.95 |
| May 11, 2026 | $9.11 |
| May 8, 2026 | $9.09 |
| May 7, 2026 | $8.99 |
| May 6, 2026 | $9.19 |
| May 5, 2026 | $9.12 |
| May 4, 2026 | $9.31 |
| May 1, 2026 | $9.40 |
| April 30, 2026 | $9.18 |
| April 29, 2026 | $9.19 |
| April 28, 2026 | $9.51 |
| April 27, 2026 | $9.29 |
| April 24, 2026 | $9.30 |
| April 23, 2026 | $9.60 |
| April 22, 2026 | $9.64 |
| April 21, 2026 | $9.26 |
| April 20, 2026 | $9.99 |
| April 17, 2026 | $9.99 |
| April 16, 2026 | $10.10 |
| April 15, 2026 | $9.88 |
| April 14, 2026 | $10.34 |
| April 13, 2026 | $10.23 |
| April 10, 2026 | $10.49 |
| April 9, 2026 | $10.42 |
| April 8, 2026 | $9.84 |
| April 7, 2026 | $9.70 |
| April 6, 2026 | $9.72 |
| April 2, 2026 | $9.50 |
| April 1, 2026 | $9.31 |
| March 31, 2026 | $9.00 |
| March 30, 2026 | $8.78 |
| March 27, 2026 | $8.67 |
| March 26, 2026 | $9.79 |
| March 25, 2026 | $9.47 |
| March 24, 2026 | $8.45 |
| March 23, 2026 | $8.45 |
| March 20, 2026 | $8.67 |
| March 19, 2026 | $8.38 |
| March 18, 2026 | $8.66 |
| March 17, 2026 | $9.71 |
| March 16, 2026 | $9.61 |
| March 13, 2026 | $9.23 |
| March 12, 2026 | $9.44 |
| March 11, 2026 | $9.36 |
| March 10, 2026 | $8.12 |
| March 9, 2026 | $8.06 |
| March 6, 2026 | $7.66 |
| March 5, 2026 | $7.67 |
| March 4, 2026 | $7.80 |
| March 3, 2026 | $7.36 |
| March 2, 2026 | $7.70 |
| Feb. 27, 2026 | $7.68 |
| Feb. 26, 2026 | $7.90 |
| Feb. 25, 2026 | $7.74 |
| Feb. 24, 2026 | $7.92 |
| Feb. 23, 2026 | $8.02 |
| Feb. 20, 2026 | $8.08 |
| Feb. 19, 2026 | $8.54 |
| Feb. 18, 2026 | $8.29 |
| Feb. 17, 2026 | $8.33 |
| Feb. 13, 2026 | $8.75 |
| Feb. 12, 2026 | $12.80 |
| Feb. 11, 2026 | $14.69 |
| Feb. 10, 2026 | $27.81 |
| Feb. 9, 2026 | $26.12 |
| Feb. 6, 2026 | $26.20 |
| Feb. 5, 2026 | $26.00 |
| Feb. 4, 2026 | $29.38 |
| Feb. 3, 2026 | $30.79 |
| Feb. 2, 2026 | $29.94 |
| Jan. 30, 2026 | $31.08 |
| Jan. 29, 2026 | $30.94 |
| Jan. 28, 2026 | $30.43 |
| Jan. 27, 2026 | $32.50 |
| Jan. 26, 2026 | $30.16 |
| Jan. 23, 2026 | $30.02 |
| Jan. 22, 2026 | $31.79 |
| Jan. 21, 2026 | $31.59 |
| Jan. 20, 2026 | $31.00 |
| Jan. 16, 2026 | $31.00 |
| Jan. 15, 2026 | $30.90 |
| Jan. 14, 2026 | $32.30 |
| Jan. 13, 2026 | $32.60 |
| Jan. 12, 2026 | $31.66 |
| Jan. 9, 2026 | $29.75 |
| Jan. 8, 2026 | $27.54 |
| Jan. 7, 2026 | $28.08 |
| Jan. 6, 2026 | $25.87 |
| Jan. 5, 2026 | $26.13 |
| Jan. 2, 2026 | $27.07 |
| Dec. 31, 2025 | $27.15 |
| Dec. 30, 2025 | $27.32 |
| Dec. 29, 2025 | $28.83 |
| Dec. 26, 2025 | $29.48 |
| Dec. 24, 2025 | $30.27 |
| Dec. 23, 2025 | $29.21 |
| Dec. 22, 2025 | $30.43 |
| Dec. 19, 2025 | $29.35 |
| Dec. 18, 2025 | $29.86 |
| Dec. 17, 2025 | $28.33 |
| Dec. 16, 2025 | $29.32 |
| Dec. 15, 2025 | $27.20 |
| Dec. 12, 2025 | $27.14 |
| Dec. 11, 2025 | $27.47 |
| Dec. 10, 2025 | $28.67 |
| Dec. 9, 2025 | $28.37 |
| Dec. 8, 2025 | $28.97 |
| Dec. 5, 2025 | $27.75 |
| Dec. 4, 2025 | $27.74 |
| Dec. 3, 2025 | $26.97 |
| Dec. 2, 2025 | $25.01 |
| Dec. 1, 2025 | $28.98 |
| Nov. 28, 2025 | $28.60 |
| Nov. 26, 2025 | $28.00 |
| Nov. 25, 2025 | $28.83 |
| Nov. 24, 2025 | $26.05 |
| Nov. 21, 2025 | $25.55 |
| Nov. 20, 2025 | $24.96 |
| Nov. 19, 2025 | $24.94 |
| Nov. 18, 2025 | $25.56 |
| Nov. 17, 2025 | $25.70 |
| Nov. 14, 2025 | $24.53 |
| Nov. 13, 2025 | $23.34 |
| Nov. 12, 2025 | $23.72 |
| Nov. 11, 2025 | $23.78 |
| Nov. 10, 2025 | $23.50 |
| Nov. 7, 2025 | $22.96 |
| Nov. 6, 2025 | $23.66 |
| Nov. 5, 2025 | $23.97 |
| Nov. 4, 2025 | $25.04 |
| Nov. 3, 2025 | $25.02 |
| Oct. 31, 2025 | $25.85 |
| Oct. 30, 2025 | $25.77 |
| Oct. 29, 2025 | $24.19 |
| Oct. 28, 2025 | $24.84 |
| Oct. 27, 2025 | $23.58 |
Key figures
- 52-week range
- $2.74–$32.60Low Oct. 23, 2026; high Jan. 13, 2026
- Average daily volume
- 817,652Past 3 months
- Market value
- $150.6M
- Dividend yield
- —
- From 52-week high
- −91.56%
Price change
- 1 month
- −48.69%
- 3 months
- −57.10%
- Year to date
- −89.87%
- 1 year
- −87.42%
$1,000 a year ago
$1,000 put into UPB at the close on Oct. 24, 2025 would be worth $126.
Price only, dividends not included.
What Wall Street says about UPB
In the past 90 days, Wall Street firms published 3 rating or price-target actions on UPB: 1 reiterated rating, 1 raised price target and 1 lowered price target.
| Action | Rating | |||
|---|---|---|---|---|
| HC Wainwright & Co. | Reiterates | Buy | $36 | |
| JP Morgan | Raises target | Neutral | $8 to $9 | |
| Truist Securities | Cuts target | Buy | $43 to $25 |
Ratings and price targets are the firms’ own opinions, reported as published.
Not investment advice.
About Upstream Bio, Inc. Common Stock
Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases. Verekitug has advanced into three separate world-wide, placebo-controlled, randomized Phase 2 clinical trials, two completed in chronic rhinosinusitis with nasal polyps (CRSwNP) and severe asthma, and one ongoing in chronic obstructive pulmonary disease (COPD).
- Headquarters
- Waltham, Mass.
- Employees
- 75
- Listed
- Oct. 11, 2024
- Sector
- Health care
- Industry
- Pharmaceutical preparations
In WallStreetDigest editions
No WallStreetDigest article about UPB is on the site yet.